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J. Semicond. > 2008, Volume 29?>?Issue 10?> 1947-1955

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A CMOS Microarray with On-Chip Decoder/Amplifier and Its Integration with a Bio-Nano-System

Zhang Lei, Gu Zhen, Yu Zhiping, He Xiangqing and Chen Yong

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Abstract: A fully integrated CMOS bio-chip is designed in a SMIC 0.18μm CMOS mixed signal process and successfully integrated with a novel bio-nano-system.The proposed circuit integrates an array of 4×4 (16 pixels) of 19μm×19μm electrodes,a counter electrode,a current mode preamplifier circuit (CMPA),a digital decoding circuit,and control logics on a single chip.It provides a -1.6～1.6V range of assembly voltage,8bit potential resolution,and a current gain of 398dB with supply voltage of 1.8V.The offset and noise are smaller than 5.9nA and 25.3pArms,respectively.Experimental results from on-chip selective assembly of 30nm poly (ethylene glycol) (PEG) coated magnetic nano-particles (MNPs) targeted at biosensor applications are included and discussed to verify the feasibility of the proposed circuits.

Key words: CMOS bio-chip, CMOS integrated microarray, fully integration, current mode preamplifier, selective assembly, magnetic nano-particles

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    Received: 18 August 2015 Revised: 03 June 2008 Online: Published: 01 October 2008

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      Zhang Lei, Gu Zhen, Yu Zhiping, He Xiangqing, Chen Yong. A CMOS Microarray with On-Chip Decoder/Amplifier and Its Integration with a Bio-Nano-System[J]. Journal of Semiconductors, 2008, 29(10): 1947-1955. ****Zhang L, Gu Z, Yu Z P, He X Q, Chen Y. A CMOS Microarray with On-Chip Decoder/Amplifier and Its Integration with a Bio-Nano-System[J]. J. Semicond., 2008, 29(10): 1947.
      Citation:
      Zhang Lei, Gu Zhen, Yu Zhiping, He Xiangqing, Chen Yong. A CMOS Microarray with On-Chip Decoder/Amplifier and Its Integration with a Bio-Nano-System[J]. Journal of Semiconductors, 2008, 29(10): 1947-1955. ****
      Zhang L, Gu Z, Yu Z P, He X Q, Chen Y. A CMOS Microarray with On-Chip Decoder/Amplifier and Its Integration with a Bio-Nano-System[J]. J. Semicond., 2008, 29(10): 1947.

      A CMOS Microarray with On-Chip Decoder/Amplifier and Its Integration with a Bio-Nano-System

      • Institute of Microelectronics,Tsinghua University,Beijing 100084,China

      • Department of Mechanical and Aerospace Engineering,California NanoSystems Institute,University of California,Los Angeles,CA 90095,USA

      • Institute of Microelectronics,Tsinghua University,Beijing 100084,China

      • Institute of Microelectronics,Tsinghua University,Beijing 100084,China

      • Department of Mechanical and Aerospace Engineering,California NanoSystems Institute,University of California,Los Angeles,CA 90095,USA

      Funds:

      國(guó)家自然科學(xué)基金

      • Received Date: 2015-08-18
      • Accepted Date: 2008-04-06
      • Revised Date: 2008-06-03
      • Published Date: 2008-11-11

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