Towards a sustainable healthcare system, the clinical-grade diagnostic platform should be decentralized into low-cost consumer-grade handheld devices, for broadly and early disease screening and diagnosis. The joint advancement of CMOS biosensors and signal-processing capability has recently transformed bulky laboratory instruments into handheld devices, leading to cost, size and weight reduction by orders of magnitude. This article gives a glimpse of the lab-on-CMOS in-vitro diagnostic (IVD) tools for point-of-care applications.